Atropen for cholinesterase inhibitor poisoning

Repeat doses based on recurrence of symptoms for 2 to 12 hours or longer depending on severity of poisoning. Auto-injector provides rapid administration.

Atnaa Atropen Busulfex Donnatal Duodote Enlon-plus Isopto Atropine Lomotil Minims Atropine Sulphate Motofen Phenohytro.

Atropen for cholinesterase inhibitor poisoning. Competitively inhibits action of ACh on autonomic effectors innervated by postganglionic nerves. Reverses muscarinic effects of cholinergic poisoning caused by agents with cholinesterase inhibitor activity by acting as a competitive antagonist of acetylcholine ast muscarinic receptors. Blocks action of acetylcholiine at parsympathetic sites in secretory glands and CNS.

For poisoning due to cholinesterase inhibitor insecticides give large doses of at least 23 mg parenterally and repeat until signs of atropine intoxication appear. For rapid type of mushroom poisoning give in doses sufficient to control parasympathetic signs before coma and CV collapse intervene. Auto-injector provides rapid administration.

Repeat doses based on recurrence of symptoms for 2 to 12 hours or longer depending on severity of poisoning. When symptoms are stable for 6 hours or more the dosing may be decreased. In severely poisoned patients the dose may need to be more than 2 times suggested dose.

The dosing interval may be decreased or continuous IV infusion may be necessary with high atropine requirements. Atropine is a muscarinic antagonist used to treat poisoning by muscarinic agents including organophosphates and other drugs. Atnaa Atropen Busulfex Donnatal Duodote Enlon-plus Isopto Atropine Lomotil Minims Atropine Sulphate Motofen Phenohytro.

Generic Name Atropine DrugBank Accession Number DB00572 Background. An alkaloid originally from Atropa belladonna but.