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Ratos e cães toleraram doses orais de 20mgkg e 10mgkg de peso corpóreo respectivamente e cães toleraram doses retais de 20mgkg de peso corpóreo sem qualquer reação. Em ratos doses de no mínimo 50mgkgdia de Cloridrato de Tramadol causaram toxicidade materna e aumento da mortalidade neonatal. Os problemas com a prole foram.