19
Oct
When mono-2-ethylhexyl adipate was added directly to the culture medium all the metabolites identified in the in vivo study were found. Urinary metabolites eliminated following the oral and dermal doses were predominantly glucuronides of oxidized metabolites of 2-EH including glucuronides of 2-ethyladipic acid 2-ethylhexanoic acid 5-hydroxy-2-ethylhexanoic.
When mono-2-ethylhexyl adipate was added directly to the culture medium all the metabolites identified in the in vivo study were found.
2 ethylhexanoic acid solubility. EUROPEAN PHARMACOPOEIA 53 INDEX To aid users the index includes a reference to the supplement where the latest version of a text can be found. Acetone51-2875 means the monograph Acetone can be found on page 2875 of Supplement 51. The dermal dosing resulted in only about 5 absorption of the 1 gkg dose with the major portion of the dose recovered unabsorbed from the dermal exposure cell at 6 hr.
Urinary metabolites eliminated following the oral and dermal doses were predominantly glucuronides of oxidized metabolites of 2-EH including glucuronides of 2-ethyladipic acid 2-ethylhexanoic acid 5-hydroxy-2-ethylhexanoic. While 2-ethylhexanoic acid glucuronidation appeared to be dose and time dependent 2-ethylhexanol glucuronidation was more stable. In vitro the first hydrolysis of DEHA appeared to be a rate limiting step.
When mono-2-ethylhexyl adipate was added directly to the culture medium all the metabolites identified in the in vivo study were found.